New age in vaccinology: the impact of the COVID-19 pandemic on third-generation vaccine development

The emergency caused by the COVID-19 pandemic required fast and effective vaccine development. Thus, third-generation technologies were pushed forward and, for first time, obtained approval human use. This review presents an analysis on production, efficacy, safety of different vaccines infectious diseases. DNA, mRNA, viral vector in phase III IV clinical trials explored here, with considerations comparisons between them. Two databases trial also analyzed, revealing that 7.9% studies are related to vaccines. Most these started 2020 (28.6%) 2021 (63.1%). target disease is primarily (92.9%), most concentrated developed countries. Scientific, economic, political factors influenced rapid development vaccines, marking beginning a new age vaccinology. knowledge during this brief period will influence future treatment